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Ketamine for depression encouraging, but questions remain around long-term use
27 Jul 2017 at 3:49pm
A world-first systematic review into the safety of ketamine as a treatment for depression shows the risks of long-term ketamine treatment remain unclear.

Link between backup immune defense, mutation seen in Crohn's disease discovered
27 Jul 2017 at 3:48pm
Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease remained a mystery.

Using latest technology, MRI provides 'one-stop-shop' to evaluate potential l...
27 Jul 2017 at 3:48pm
Using the latest techniques, MRI can provide a 'one-stop-shop' method for evaluation of potential living liver donors, according to an article.


Researchers crack the smile, describing three types by muscle movement
27 Jul 2017 at 3:48pm
The smile may be the most common and flexible expression, used to reveal some emotions, cover others and manage social interactions that have kept communities secure and organized for millennia. But how do we tell one kind of smile from another?

Biochemists link synthetic compound to hunger-hormone production
27 Jul 2017 at 3:48pm
A human-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway, new research suggest.


Genome-wide cancer 'dependency map' now revealed
27 Jul 2017 at 11:20am
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers have identified more than 760 genes upon which cancer cells from multiple types are strongly dependent for their growth and survival. While many of these dependencies are specific to certain cancer types, about 10 percent are common across multiple cancers, suggesting that a relatively small number of therapies may combat multiple cancer types. Mutations accounted for only a small percentage of dependencies.


Co-infection with two common gut pathogens worsens malnutrition in mice
27 Jul 2017 at 11:18am
Two gut pathogens commonly found in malnourished children combine to worsen malnutrition and impair growth in laboratory mice, according to new research.


MKTP surgery has long-term benefit for restoring skin pigmentation in vitilig...
27 Jul 2017 at 11:18am
Skin transplant surgery has long-term benefit for restoring skin pigmentation caused by the skin disease vitiligo, new research shows. In a retrospective study, researchers found that a majority of areas of the skin treated with surgery still had 'very good to excellent' color match pigmentation five years later.


Social influences can override aggression in male mice, study shows
27 Jul 2017 at 11:18am
A cluster of nerve cells in the male mouse's brain have been identified that, when activated, triggers territorial rage in a variety of situations. Activating the same cluster has no such effect on female mice.

Errors made by 'DNA spellchecker' revealed as important cause of cancer
27 Jul 2017 at 11:18am
Important processes that create mutations that cause cancer have been identified by researchers studying the genomes of more than 1,000 tumors. Many mutations in human cancers are caused by mistakes made by a repair mechanism or 'DNA spellchecker' rather than the actual damage to DNA caused by the environment. Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes, add the investigators.


Which type of cell to become: Decision through indecision
27 Jul 2017 at 11:16am
From the moment of fertilization, building a human body involves a series of choices where cells generated by cell division must elect which of the myriad types of cell they will become. How does this decision occur? New research suggests that fate decision is not a unique programmed event, as was believed, but the outcome of a very dynamic process.


Lab-created mini-brains reveal how growing organ maintains neuronal balance
27 Jul 2017 at 11:16am
Scientists can now explore in a laboratory dish how the human brain develops by creating organoids -- distinct, three-dimensional regions of the brain. Scientists coaxed early stage stem cells to create and fuse two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons.


Hunting-related pathogen exposure not just for adult males
27 Jul 2017 at 11:15am
Hunting and slaughtering wild animals in Western and Central Africa can put humans at risk of contracting zoonotic infections, including Ebola virus and Lassa virus. While previous studies have suggested that this risky hunting behavior is mostly limited to adult males, a new study finds that women and children also participate.


Scientists block evolution's molecular nerve pruning in rodents
27 Jul 2017 at 11:15am
Researchers investigating why some people suffer from motor disabilities report they may have dialed back evolution's clock a few ticks by blocking molecular pruning of sophisticated brain-to-limb nerve connections in maturing mice.


Long-sought mechanism of metastasis is discovered in pancreatic cancer
27 Jul 2017 at 11:15am
An important discovery establishes a cause of metastasis in pancreatic cancer. Using organoids grown from patient tissues and transplanted in mouse models of the illness, the team pinpoints an epigenetic re-programming of gene enhancers that returns cancerous cells to a more primitive developmental state, dating back to the formation of the pancreas, in which cells multiply rapidly and are not yet anchored in tissue.



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