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(Health-NewsWire.Net, December 05, 2015 ) Charleston, NC -- Being an era of people seeking for general fitness, longevity is no longer the only key buzzword but its healthy and productive living as long as they live. ‘Dying young’ is what people aim for. This doesn’t mean early death but it is death at the age of 80 or above when you still look young and healthy.
Now all this makes our scientists do research to address the needs of people and come up with something promising. So that has made scientists to test Metformin, a drug used widely in the treatment of type 2 diabetes for more than half a century, on humans for its unique anti-aging properties.
How does a human body grow physically? As we grow our cells divide to facilitate our bodies to do its normal functions properly. Now in this process of cell division there is a chance of improper cell growth which in one way causes Cancer or Alzheimer’s. Cancer is due to increase in cell mutations beyond the body control and it culminates in tumor growths. Alzheimer's - a type of dementia, is an irreversible, progressive brain disorder, which causes problems with memory, thinking and behavior is also due to the improper functioning of the brain cells. There are natural remedies for health problems of all kinds but all within limits.
Metformin is usually used for the treatment of type 2 diabetes which helps in reducing the amount of glucose produced by the liver. But the researchers have found a link between Metformin and anti-aging. Metformin has the ability to slow down the aging process by increasing the oxygen molecules released into an individual cell, thus promotes longevity and boost robustness.
Anti-aging can be considered as a possible treatment for various diseases like Diabetes, Parkinson’s and Alzheimer’s. This aspect has made the Food and Drug Administration (FDA) to do a clinical trial in the U.S. known as Targeting Aging with Metformin (TAME) study. The research process includes 3000 elderly people who either suffer from or have high chances of developing diseases like heart problems, cancer or cognitive problems. These people will be given Metformin and will be monitored constantly for six years to see the changes in them. This will be a double-blind, placebo-controlled study, mainly to see if Metformin prevents aging-related diseases they don’t have as well as prevents diabetes and increases their life spans.
"In terms of a public health impact, this would be the most important medical intervention in the modern era," Dr. Jay Olshansky, a professor in the School of Public Health at the University of Illinois Chicago, told National Geographic, speaking about the TAME trial for an episode of the science program Breakthrough.
What motivated the FDA researchers to go for a TAME study? In 2005, researchers had found a connection between Metformin and decreased risk rate of cancer in diabetic patients. The Metformin research done by Belgium researchers on roundworms had shown positive results stating that the round worms aged slower and stayed healthier. The research of Metformin on mice showed increased lifespan by nearly 40% and also development of stronger bones. Research done by Cardiff University in the year 2014 found that the diabetic patients taking Metformin had longer life period.
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